Allosteric activation of glutamate dehydrogenase testing - ACTIVATION OF GLUTAMATE DEHYDROGENASE BY 3'
. 1. 1. 4 Glutamate dehydrogenase. Glutamate dehydrogenase (GDH) encoded by the GLUD1 gene catalyzes the oxidation of glutamate to α-ketoglutarate and ammonia . Although protein-derived leucine stimulates this enzyme allosterically, this action can be blocked by glucose causing complete inhibition of ammonia production [53–57].
lutamate dehydrogenase exercise testing 175–178 insulin secretion during exercise 172, 173 allosteric regulation ADP activation 91
Background Activating mutations in the GLUD1 gene (which encodes for the intra-mitochondrial enzyme glutamate dehydrogenase, GDH) cause the hyperinsulinism–hyperammonaemia (HI/HA) syndrome.
Related PubMed/MEDLINE Info. Activation of glutamate dehydrogenase by leucine and Nucleotide allosteric regulation of the glutamate dehydrogenases of
GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis.
Physiological Consequences of Loss of Allosteric Activation of Yeast NAD +-specific Isocitrate Dehydrogenase*